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Qom Univ Med Sci J 2020, 14(4): 40-47 Back to browse issues page
Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats
Mehrdad Farivar1 , Zahra Hooshmandi 2, Mahbubeh Setorki3 , Sabrieh Amini1
1- Department of Biology, Sanandaj Branch, Islamic Azad University
2- Department of Biology, Sanandaj Branch, Islamic Azad University , zhoushmandi@yahoo.com
3- Department of Biology, Izeh Branch, Islamic Azad University
Abstract:   (1393 Views)
Background and Objectives: Most of the phenomena observed during brain ischemia and reperfusion are associated with damage to the membrane structure. Oxidative stress results in an imbalance between high oxygen consumption and low levels of endogenous antioxidants. It is known that 1,8-cineole is a strong antioxidant. The present study was carried out to evaluate the effect of 1,8-cineole on ischemia/reperfusion (I/R)-induced brain injury in rats.
 
Methods: Wistar adult male rats weighing 250-300 g were divided into five groups of control, normal saline-treated I/R, 5-mg/kg 1,8-cineole-treated I/R, 10-mg/kg 1,8-cineole-treated I/R, and 20-mg/kg 1,8-cineole-treated I/R. The 1,8-cineole was administered through intraperitoneal injection. The cerebral hypoperfusion injury was induced in the adult male rats by occluding the bilateral common carotid arteries for 30 min, followed by 5 days of reperfusion. The data were analyzed by one-way analysis of variance and Tukey's multiple comparison test at a p-value of < 0.05.
 
Results: The results revealed that the administration of 1,8-cineole significantly increased passive avoidance memory (P<0.05).
 
Conclusion: Our findings demonstrated the beneficial effects of 1,8-cineole on behavioral impairments after I/R-induced brain injury.
 
Keywords: Brain, Eucalyptol, Hypoxia-ischemia, Memory and learning tests, Rats.
Full-Text [PDF 1112 kb]   (265 Downloads)    
Type of Study: Original Article | Subject: فیزیولوژی
Received: 2020/04/19 | Accepted: 2020/06/23 | Published: 2020/06/30
References
1. Xing B, Chen H, Zhang M, Zhao D, Jiang R, Liu X, et al. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke 2008;39(8):2362-9. PMID: 18583563 [DOI:10.1161/STROKEAHA.107.507939]
2. Hosseinzadeh H, Parvardeh S, Asl MN, Sadeghnia HR, Ziaee T. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine 2007;14(9):621-7. PMID: 17291733 [DOI:10.1016/j.phymed.2006.12.005]
3. Peng Z, Xiao P, Guo H, Liu Q. Effect of early hyperbaric oxygen on neuronal apoptosis and learning and memory of cerebral ischemia-reperfusion injury in rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009;34(6):468-75. PMID: 19587426
4. Santos FA, Rao VS. Antiinflammatory and antinociceptive effects of 1, 8‐cineole a terpenoid oxide present in many plant essential oils. Phytother Res 2000;14(4):240-4. PMID: 10861965 https://doi.org/10.1002/1099-1573(200006)14:4<240::AID-PTR573>3.0.CO;2-X [DOI:10.1002/1099-1573(200006)14:43.0.CO;2-X]
5. https://doi.org/10.1002/1099-1573(200006)14:4<240::AID-PTR573>3.0.CO;2-X https://doi.org/10.1002/1099-1573(200006)14:4<240::AID-PTR573>3.0.CO;2-X [DOI:10.1002/1099-1573(200006)14:43.0.CO;2-X]
6. Ciftci O, Ozdemir I, Tanyildizi S, Yildiz S, Oguzturk H. Antioxidative effects of curcumin, β-myrcene and 1, 8-cineole against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver. Toxicol Ind Health 2011;27(5):447-53. PMID: 21245202 [DOI:10.1177/0748233710388452]
7. Ryu S, Park H, Seol GH, Choi IY. 1, 8‐C ineole ameliorates oxygen‐glucose deprivation/reoxygenation‐induced ischaemic injury by reducing oxidative stress in rat cortical neuron/glia. J Pharm Pharmacol 2014;66(12):1818-26. PMID: 25088014 [DOI:10.1111/jphp.12295]
8. Masoumi-Ardakani Y, Mandegary A, Esmaeilpour K, Najafipour H, Sharififar F, Pakravanan M, et al. Chemical composition, anticonvulsant activity, and toxicity of essential oil and methanolic extract of Elettaria cardamomum. Planta Med 2016;82(17):1482-6. PMID: 27433883 [DOI:10.1055/s-0042-106971]
9. Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia. Surg Neurol 2006;66(3):232-45. PMID: 16935624 [DOI:10.1016/j.surneu.2005.12.028]
10. Daemen MA, van't Veer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M, et al. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 1999;104(5):541-9. PMID: 10487768 [DOI:10.1172/JCI6974]
11. Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, et al. Neuroprotective effect of curcumin against cerebral ischemia-reperfusion via mediating autophagy and inflammation. J Mol Neurosci 2018;64(1):129-39. PMID: 29243061 [DOI:10.1007/s12031-017-1006-x]
12. Juergens UR, Engelen T, Racké K, Stöber M, Gillissen A, Vetter H. Inhibitory activity of 1, 8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes. Pulm pharmacol Ther 2004;17(5):281-7. PMID: 15477123 [DOI:10.1016/j.pupt.2004.06.002]
13. Qian ZJ, Jung WK, Kim SK. Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin, Rana catesbeiana Shaw. Bioresour Technol 2008;99(6):1690-8. PMID: 17512726 [DOI:10.1016/j.biortech.2007.04.005]
14. Moss M, Oliver L. Plasma 1, 8-cineole correlates with cognitive performance following exposure to rosemary essential oil aroma. Ther Adv Psychopharmacol 2012;2(3):103-13. PMID: 23983963 [DOI:10.1177/2045125312436573]
15. Paul K, Ganguly U, Chakrabarti S, Bhattacharjee P. Is 1, 8-Cineole-Rich extract of small cardamom seeds more effective in preventing Alzheimer's disease than 1, 8-Cineole alone? NeuroMolecular Med 2020;22(1):150-8. PMID: 31628580 [DOI:10.1007/s12017-019-08574-2]
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Farivar M, Hooshmandi Z, Setorki M, Amini S. Protective Effect of 1,8-cineole on Learning and Memory Impairment Induced by Cerebral Hypoperfusion in Male Rats. Qom Univ Med Sci J. 2020; 14 (4) :40-47
URL: http://journal.muq.ac.ir/article-1-2795-en.html


Volume 14, Issue 4 (June 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی قم Qom University of Medical Sciences Journal
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