Volume 16, Issue 5 (August 2022)                   Qom Univ Med Sci J 2022, 16(5): 402-413 | Back to browse issues page

Research code: IR.IAU.TMU.REC.1398.112
Ethics code: IR.IAU.TMU.REC.1398.112


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kousha S, Lotfi Kashani F, Vaziri S, Nafisi N. Predicting the Immune System Performance Based on Stress Coping Strategies and Defense Mechanisms in Women with Breast Cancer. Qom Univ Med Sci J 2022; 16 (5) :402-413
URL: http://journal.muq.ac.ir/article-1-3480-en.html
1- Department of Psychology, Rudehen Branch, Islamic Azad University, Rudehen, Iran.
2- Department of Psychology, Medical Sciences Branch, Islamic Azad University, Tehran, Iran. , lotfi.kashani@gmail.com
3- Department of General Surgery, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), Iran University of Medical Sciences, Tehran, Iran.
Abstract:   (817 Views)
Background and Objectives:  Breast cancer, as the most common cancer, is the cause of death in many women around the world. This study aims to predict the immune system performance based on stress coping methods and defense mechanisms in women with breast cancer.
Methods: The study population includs all women with breast cancer in Tehran and Guilan provinces of Iran in 2019, from whom 250 were selected by a purposive sampling method. Data were collected using the warning signs of immunodeficiency list, the Defense Style Questionnaire, and the Multidimensional Coping Inventory. The collected data were analyzed using Pearson correlation test and multiple regression analysis in SPSS software, version 22.
Results: The results of regression analysis showed that the emotion-focused coping as well as mature, neurotic, and immature defense mechanisms could significantly predict the immune system performance (P<0.05). Together, these variables were able to explain 28% of the variance in the immune performance.
Conclusion: In women with breast cancer, the immune system function can be predicted by their used defense mechanisms and stress coping strategies.
Full-Text [PDF 4523 kb]   (338 Downloads)    
Type of Study: Original Article | Subject: روانشناسی
Received: 2022/05/25 | Accepted: 2022/06/25 | Published: 2022/08/1

References
1. Hühn D, Martí‐Rodrigo P, Mouron S, Hansel C, Tschapalda K, Porebski B, et al. Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells. Mol Oncol. 2022; 16(1):148-65. [DOI:10.1002/1878-0261.13083] [PMID] [PMCID] [DOI:10.1002/1878-0261.13083]
2. Breidenbach C, Heidkamp P, Hiltrop K, Pfaff H, Enders A, Ernstmann N, et al. Prevalence and determinants of anxiety and depression in long-term breast cancer survivors. BMC psychiatry. 2022; 22(1):101. [DOI:10.1186/s12888-022-03735-3] [PMID] [PMCID] [DOI:10.1186/s12888-022-03735-3]
3. Dijkshoorn AB, van Stralen HE, Sloots M, Schagen SB, Visser‐Meily JM, Schepers VP. Prevalence of cognitive impairment and change in patients with breast cancer: a systematic review of longitudinal studies. Psycho‐Oncol. 2021; 30(5):635-48. [DOI:10.1002/pon.5623] [PMID] [PMCID] [DOI:10.1002/pon.5623]
4. Takahashi A, Flanigan ME, McEwen BS, Russo SJ. Aggression, social stress, and the immune system in humans and animal models. Front Behav Neurosci. 2018: 22;12:56. [DOI:10.3389/fnbeh.2018.00056] [PMID] [PMCID] [DOI:10.3389/fnbeh.2018.00056]
5. Mueller B, Figueroa A, Robinson-Papp J. Structural and functional connections between the autonomic nervous system, hypothalamic-pituitary-adrenal axis, and the immune system: a context and time dependent stress response network. Neurol Sci. 2022; 43(2):1-0. [DOI:10.1007/s10072-021-05810-1] [PMID] [DOI:10.1007/s10072-021-05810-1]
6. Adamo SA. The stress response and immune system share, borrow, and reconfigure their physiological network elements: Evidence from the insects. Horm Behav. 2017; 88:25-30. [DOI:10.1016/j.yhbeh.2016.10.003] [PMID] [DOI:10.1016/j.yhbeh.2016.10.003]
7. Crucian BE, Makedonas G, Sams CF, Pierson DL, Simpson R, Stowe RP, et al. Countermeasures-based improvements in stress, immune system dysregulation and latent herpesvirus reactivation onboard the International Space Station-Relevance for deep space missions and terrestrial medicine. Neurosci Biobehav Rev. 2020; 115:68-76. [DOI:10.1016/j.neubiorev.2020.05.007] [PMID] [DOI:10.1016/j.neubiorev.2020.05.007]
8. Kim MS, Duda JL. The coping process: Cognitive appraisals of stress, coping strategies, and coping effectiveness. SP Psychol. 2003; 17(4):406-25. [DOI:10.1123/tsp.17.4.406] [DOI:10.1123/tsp.17.4.406]
9. Greer JA, Jacobs JM, El-Jawahri A, Nipp RD, Gallagher ER, Pirl WF, et al. Role of patient coping strategies in understanding the effects of early palliative care on quality of life and mood. J Clinic Oncol. 2018; 36(1):53. [DOI:10.1200/JCO.2017.73.7221] [PMID] [PMCID] [DOI:10.1200/JCO.2017.73.7221]
10. Nipp RD, El‐Jawahri A, Fishbein JN, Eusebio J, Stagl JM, Gallagher ER, et al. The relationship between coping strategies, quality of life, and mood in patients with incurable cancer. Cancer. 2016; 122(13):2110-6. [DOI:10.1002/cncr.30025] [PMID] [PMCID] [DOI:10.1002/cncr.30025]
11. Chirico A, Lucidi F, Merluzzi T, Alivernini F, De Laurentiis M, Botti G, Giordano A. A meta-analytic review of the relationship of cancer coping self-efficacy with distress and quality of life. Oncotarget. 2017; 8(22):36800. [DOI:10.18632/oncotarget.15758] [DOI:10.18632/oncotarget.15758]
12. Nipp RD, Greer JA, El-Jawahri A, Moran SM, Traeger L, Jacobs JM, et al. Coping and prognostic awareness in patients with advanced cancer. J Clin Oncol. 2017; 35(22):2551. [DOI:10.1200/JCO.2016.71.3404] [PMID] [PMCID] [DOI:10.1200/JCO.2016.71.3404]
13. Czerw A, Religioni U, Deptała A. Assessment of pain, acceptance of illness, adjustment to life with cancer and coping strategies in breast cancer patients. Breast Cancer. 2016; 23(4):654-61. [DOI:10.1007/s12282-015-0620-0] [PMID] [PMCID] [DOI:10.1007/s12282-015-0620-0]
14. Renzi C, Perinel G, Arnaboldi P, Gandini S, Vadilonga V, Rotmensz N, et al. Memories of paternal relations are associated with coping and defense mechanisms in breast cancer patients: an observational study. BMC psychol. 2017; 5(1):1-0. [DOI:10.1186/s40359-017-0206-z] [PMID] [PMCID] [DOI:10.1186/s40359-017-0206-z]
15. Hyphantis T, Almyroudi A, Paika V, Degner LF, Carvalho AF, Pavlidis N. Anxiety, depression and defense mechanisms associated with treatment decisional preferences and quality of life in non‐metastatic breast cancer: a 1‐year prospective study. Psychol‐Oncol. 2013; 22(11):2470-7. [DOI:10.1002/pon.3308] [PMID] [DOI:10.1002/pon.3308]
16. Talepasand S, Mahfar F. Relationship Between Defense Mechanisms and the Quality of Life in Women With Breast Cancer. Inter J Cancer Manage. 2018; 11(1):e11116. [DOI:10.5812/ijcm.11116] [DOI:10.5812/ijcm.11116]
17. Vaillant GE. Ego mechanisms of defense: a guide for clinicans and researchers. American Psychiatric Pub; 1992. [Link]
18. Stepanchuk E, Zhirkov A, Yakovleva A. The coping strategies, psychological defense mechanisms and emotional response to the disease in Russian patients with chronic leukemia. Procedia-Soc Behav Sci. 2013; 86:248-55. [DOI:10.1016/j.sbspro.2013.08.559] [DOI:10.1016/j.sbspro.2013.08.559]
19. Modell V, Gee B, Lewis DB, Orange JS, Roifman CM, Routes JM, et al. Global study of primary immunodeficiency diseases (PI)-diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation. Immunol res. 2011; 51(1):61-70. [DOI:10.1007/s12026-011-8241-y] [PMID] [DOI:10.1007/s12026-011-8241-y]
20. Tarkhan M, Tavakol M, Khalatbari J. [Predicting the warning signs of immunodeficiency through sense of humor and explanatory styles with the mediating role of the locus of control and personality type in nurses (Persian)]. MEJDS. 2020; 10 :115 . [Link]
21. Endler NS, Parker JD. Assessment of multidimensional coping: Task, emotion, and avoidance strategies. Psychol assess. 1994; 6(1):50. [DOI:10.1037/1040-3590.6.1.50] [DOI:10.1037/1040-3590.6.1.50]
22. Seydi M, Akhbari B, Abdollahi I, Abad SK, Biglarian A. Confirmatory factor analysis, reliability, and validity of the persian version of the coping strategies questionnaire for iranian people with nonspecific chronic neck pain. J Manipulative Physiol Ther. 2021; 44(1):72-84. [DOI:10.1016/j.jmpt.2020.08.004] [PMID] [DOI:10.1016/j.jmpt.2020.08.004]
23. Andrews G, Singh M, Bond M. The defense style questionnaire. J Nervous and mental Disease. 1993. [DOI:10.1037/t20765-000] [DOI:10.1037/t20765-000]
24. Heidari Nasab L, Mansouri M, Azadfallah P, Shaieeri MR. [Validity and reliability of defens style questionaire (DSQ-40) in Iranian samples (Persian)]. Clin Psychol Pers. 2007; 5(1):11-27. [Link]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2025 CC BY-NC 4.0 | Qom University of Medical Sciences Journal

Designed & Developed by : Yektaweb