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Shaheli M, Yaghobi R, Ramzi M. Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia. Qom Univ Med Sci J 2023; 17 : 2693.1
URL: http://journal.muq.ac.ir/article-1-3557-en.html
Prevalence of Torque Teno Virus, Hepatitis and Cytomegalovirus Infection in Iranian Patients With Different Types of leukemia
Marjan Shaheli * 1, Ramin Yaghobi2 , Mani Ramzi3
1- Department of Biology, Faculty of Basic Sciences, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran. , Marjan.Shaheli@iau.ac.ir
2- Shiraz Transplant Research Center, Shiraz University of Medical Sciences,Shiraz, Iran.
3- Hematology and Bone Marrow Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (568 Views)
Background and Objectives: Torque teno virus (TTV) infection can be seen in different types of leukemia and may affect clinical outcomes. This study aims to investigate the prevalence of TTV, hepatitis B and C virus, and cytomegalovirus (CMV) in Iranian patients with different types of leukemia.
Methods: In this descriptive cross-sectional study, 95 patients with different types of leukemia participated. The molecular prevalence of TTV infection was evaluated using the semi-nested PCR method. The prevalence of HBs-Ag and HCV-Ab viruses was measured by the ELISA method. Also, the prevalence of active CMV infection was investigated by the semi-quantitative antigenemia test. The data analysis was done in SPSS software version 12 using logistic regression analysis, chi-square test, and Fisher’s exact test.
Results: The TTV infection was found in 40 out of 95 patients (42.1%). The presence of HBs-Ag was reported in 27 out of 95 patients (28.4%). HCV-Ab was found in 18 out of 69 patients (26.1%), and active CMV infection was found in 11 out of 69 (15.9%). Among 40 leukemia patients with TTV infection, 15 (37.5%) had hepatitis B, 14 (35%) had hepatitis C, and 7 (17.5%) had CMV infection.
Conclusion: The high prevalence of single or comorbid TTV infection among Iranian patients with leukemia emphasizes the importance of this virus in causing or aggravating the clinical complications observed in these patients.
Article number: 2693.1
Keywords: Torque teno virus, Leukemia, Hepatitis, Cytomegalovirus
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Type of Study: Original Article | Subject: میکروب شناسی
Received: 2022/08/28 | Accepted: 2022/09/26 | Published: 2023/08/1
References
1. Lawson JS, Salmons B, Glenn WK. Oncogenic viruses and breast cancer: Mouse mammary tumor virus (MMTV), bovine leukemia virus (BLV), human papilloma virus (HPV), and Epstein-barr virus (EBV). Front Oncol. 2018; 8:1. [DOI:10.3389/fonc.2018.00001] [PMID] [DOI:10.3389/fonc.2018.00001]
2. Leijonhufvud G, Bajalan A, Teixeira Soratto TA, Gustafsson B, Bogdanovic G, Bjerkner A, et al. Better detection of Torque teno virus in children with leukemia by metagenomic sequencing than by quantitative PCR. J Med Virol. 2022; 94(2):634-41. [DOI:10.1002/jmv.27409] [PMID] [DOI:10.1002/jmv.27409]
3. Chu CC, Zhang L, Dhayalan A, Agagnina BM, Magli AR, Fraher G, et al. Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera. Mol Med. 2011; 17(11-12):1338-48. [DOI:10.2119/molmed.2010.00110] [PMID] [DOI:10.2119/molmed.2010.00110]
4. Spandole S, Cimponeriu D, Berca LM, Mihăescu G. Human anelloviruses: An update of molecular, epidemiological and clinical aspects. Arch Virol. 2015; 160(4):893-908. [DOI:10.1007/s00705-015-2363-9] [PMID] [DOI:10.1007/s00705-015-2363-9]
5. Hino S, Miyata H. Torque teno virus (TTV): Current status. Rev Med Virol. 2007; 17(1):45-57. [DOI:10.1002/rmv.524] [PMID] [DOI:10.1002/rmv.524]
6. Shiramizu B, Yu Q, Hu N, Yanagihara R, Nerurkar VR. Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemia. Pediatr Hematol Oncol. 2002; 19(8):543-51. [DOI:10.1080/08880010290097396] [PMID] [DOI:10.1080/08880010290097396]
7. Kulifaj D, Durgueil-Lariviere B, Meynier F, Munteanu E, Pichon N, Dubé M, et al. Development of a standardized real time PCR for Torque teno viruses (TTV) viral load detection and quantification: A new tool for immune monitoring. J Clin Virol. 2018; 105:118-27. [DOI:10.1016/j.jcv.2018.06.010] [PMID] [DOI:10.1016/j.jcv.2018.06.010]
8. Khudair EA, Al-Shuwaikh AM, Farhan NM. Detection of TTV antigen in patients with hepatitis HBV and HCV. Iraqi J Med Sci. 2019. 17(1):43-9. [DOI:10.22578/IJMS.17.1.7] [DOI:10.22578/IJMS.17.1.7]
9. Shaheli M, Yaghobi R, Rezaeian A, Iravani Saadi M, Ramzi M. Study of the associations between TT Virus single and mixed infections with leukemia. Jundishapur J Microbiol. 2015; 8(4):e18212. [DOI:10.5812/jjm.8(4)2015.18212] [DOI:10.5812/jjm.8(4)2015.18212]
10. Pradier A, Masouridi-Levrat S, Bosshard C, Dantin C, Vu DL, Zanella MC, et al. Torque teno virus as a potential biomarker for complications and survival after allogeneic hematopoietic stem cell transplantation. Front Immunol. 2020; 11:998. [DOI:10.3389/fimmu.2020.00998] [PMID] [DOI:10.3389/fimmu.2020.00998]
11. Reshetnyak VI, Maev IV, Burmistrov AI, Chekmazov IA, Karlovich TI. Torque teno virus in liver diseases: On the way towards unity of view. World J Gastroenterol. 2020; 26(15):1691-707. [DOI:10.3748/wjg.v26.i15.1691] [PMID] [PMCID] [DOI:10.3748/wjg.v26.i15.1691]
12. Pan S, Yu T, Wang Y, Lu R, Wang H, Xie Y, et al. Identification of a torque teno mini virus (TTMV) in hodgkin's lymphoma patients. Front Microbiol. 2018; 9:1680. [DOI:10.3389/fmicb.2018.01680] [PMID] [DOI:10.3389/fmicb.2018.01680]
13. Zhong S, Yeo W, Tang MW, Lin XR, Mo F, Ho WM, et al. Gross elevation of TT virus genome load in the peripheral blood mononuclear cells of cancer patients. Ann N Y Acad Sci. 2001; 945:84-92. [DOI:10.1111/j.1749-6632.2001.tb03868.x] [PMID] [DOI:10.1111/j.1749-6632.2001.tb03868.x]
14. Fanci R, De Santis R, Zakrzewska K, Paci C, Azzi A. Presence of TT virus DNA in bone marrow cells from hematologic patients. New Microbiol. 2004; 27(2):113-7. [PMID]
15. Maggi F, Focosi D, Albani M, Lanini L, Vatteroni ML, Petrini M, et al. Role of hematopoietic cells in the maintenance of chronic human torquetenovirus plasma viremia. J Virol. 2010; 84(13):6891-3. [DOI:10.1128/JVI.00273-10] [PMID] [DOI:10.1128/JVI.00273-10]
16. Schmitz J, Kobbe G, Kondakci M, Schuler E, Magorsch M, Adams O. The value of torque teno virus (TTV) as a marker for the degree of immunosuppression in adult patients after hematopoietic stem cell transplantation (HSCT). Biol Blood Marrow Transplant. 2020; 26(4):643-50. [DOI:10.1016/j.bbmt.2019.11.002] [PMID] [DOI:10.1016/j.bbmt.2019.11.002]
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