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Heidari F, Komeili-Movahhed T, Moslehi A. Effect of Chlorogenic Acid on the Heart Tissue in Male C57/BL6 Mice With Endoplasmic Reticulum Stress. Qom Univ Med Sci J 2024; 18 : 65.9
URL: http://journal.muq.ac.ir/article-1-3862-en.html
URL: http://journal.muq.ac.ir/article-1-3862-en.html
1- Department of Anatomical Sciences, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
2- Department of Biochemistry and Genetics, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
3- Department of Physiology and Pharmacology, School of Medicine, Qom University of Medical Sciences, Qom, Iran. ,moslehi2000@gmail.com
2- Department of Biochemistry and Genetics, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
3- Department of Physiology and Pharmacology, School of Medicine, Qom University of Medical Sciences, Qom, Iran. ,
Abstract: (476 Views)
Background and Objectives: Endoplasmic reticulum (ER) stress is one of important factors in pathophysiology of fatty liver, infertility, gastric ulcer, and even cardiac disorders. Chlorogenic acid (CA) is an herbal compound with many antioxidant and anti-inflammatory properties. This study aims to evaluate the protective effectiveness of CA in reducing ER stress induced by tunicamycin (TM) in the heart of male C57/BL6 mice.
Methods: In this study, 36 male C57/BL6 mice were divided into six groups: Saline, Vehicle, CA, ER stress, ER stress-CA 20 mg/kg and ER stress-CA 50 mg/kg. ER stress was induced by intraperitoneal injection of TM. The CA was injected intraperitoneally one hour before TM injection. Thirty hours after TM injection, the animals were sacrificed and a part of their heart was kept in 10% formaldehyde and another part was kept in -80oC.
Results: The CA reduced GRP78 and Malondialdehyde levels, while total antioxidant capacity increased after CA administration. Decreased cross section of muscle fibers and increased interventricular wall thickness caused by ER stress were also improved.
Conclusion: The CA can improve histological and cellular changes caused by ER stress in the heart of male C57/Bl6 mice by reducing oxidative stress and ER stress.
Methods: In this study, 36 male C57/BL6 mice were divided into six groups: Saline, Vehicle, CA, ER stress, ER stress-CA 20 mg/kg and ER stress-CA 50 mg/kg. ER stress was induced by intraperitoneal injection of TM. The CA was injected intraperitoneally one hour before TM injection. Thirty hours after TM injection, the animals were sacrificed and a part of their heart was kept in 10% formaldehyde and another part was kept in -80oC.
Results: The CA reduced GRP78 and Malondialdehyde levels, while total antioxidant capacity increased after CA administration. Decreased cross section of muscle fibers and increased interventricular wall thickness caused by ER stress were also improved.
Conclusion: The CA can improve histological and cellular changes caused by ER stress in the heart of male C57/Bl6 mice by reducing oxidative stress and ER stress.
Article number: 65.9
Type of Study: Original Article |
Subject:
فیزیولوژی
Received: 2023/11/15 | Accepted: 2023/12/16 | Published: 2024/04/29
Received: 2023/11/15 | Accepted: 2023/12/16 | Published: 2024/04/29
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