Volume 8, Issue 4 (9-2014)                   Qom Univ Med Sci J 2014, 8(4): 34-43 | Back to browse issues page

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Izanlo H, Ahmadi Jebelli M, Mjidi G, Khazaei M, Tashayoe H R, Vazirirad V, et al . The Antibacterial Effect of Polypropylenimine-G2 Dendrimer on Escherichia coli, Enterobacter cloacae , Bacillus subtilis, and Staphylococcus aureus. Qom Univ Med Sci J 2014; 8 (4) :34-43
URL: http://journal.muq.ac.ir/article-1-406-en.html
1- Qom University of Medical Sciences
2- Kurdistan University of Medical Sciences
3- Qom University of Medical Sciences , gharibmajidi@gmail.com
4- Tehran University of Medical Sciences
5- Islamic Azad University, Tehran Medical Sciences Branch
6- Islamic Azad University, Qom Branch
7- Islamic Azad University, Sciences & Research Branch
8- National Water & Wastewater Engineering Company
Abstract:   (6095 Views)

Backgrounds and Objectives:Dendrimers are a new class of synthetic macromolecules, which have many applications in medical sciences.This study was carried out with the purpose ofinvestigating the antibacterial effect of polypropylenimine-G2 (PPI-G2) dendrimer on some bacterial species.

Methods:In this study, the antibacterial effects of PPI-G2 dendrimer were studied by disk diffusion and microdilution method. PPI-G2 dendrimer in concentrations of 0.5, 5, 50, and 500µg/ml were inoculated onto blank disks and placed in Mueller-Hinton agar media. Zone of inhibition was investigated by bacterial inoculation according to the McFarland standard 0.5. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of PPI-G2 dendrimer in the concentrations of 0.05, 0.5, 5, 50, and 500µg/ml, were determined using microdilution method in nutrient broth media.

Results: In this study, antibacterial activity of dendrimer increased with increasing their concentration in the disk. Zone of inhibition in the concentration of 500μg/ml for E. coli,Enterobacter cloacae, Bacillus subtilis, and Staphylococcus aurouswere 19, 20, 25, and 21mm, respectively. The MIC for Enterobacter cloacae, Bacillus subtilis, and Staphylococcus aurous was 5μg/ml and for E. coli was 500μg/ml. In addition, the MBC for Bacillus subtilis and Staphylococcus aurous was 50μg/ml and for E. coli and Enterobacter cloacae was 500μg/ml.

Conclusion: The findings of this study showed that PPI-G2 dendrimer has antibacterial effects. However, use of the dendrimer for drinking water disinfection requires further and wider studies.

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Type of Study: Original Article |
Received: 2016/03/10 | Accepted: 2016/03/10 | Published: 2016/03/10

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