Qom University of Medical Sciences Journal

Background and Objectives: Metabolic changes in postprandial stage, especially after consumption of high fat meal cause atherosclerosis and increase the risk of cardiovascular diseases. Apple cider vinegar is an acidic juice with useful medicinal effects. In this research; we investigated acute effects of apple cider vinegar intake on some of the biochemical atherosclerosis risk factors in high cholesterol fed rabbits. Methods: Thirty two male New Zealand rabbits were randomly divided into four groups: normal diet group, high cholesterol diet group (%1cholesterol), %1 cholesterol with 5ml apple cider vinegar group, %1 cholesterol with 10ml apple cider vinegar group. The C-Reactive Protein (CRP), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), total cholesterol (TC), malondialdehyde (MDA), oxidized-LDL (OxLDL), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetate transaminase (SGOT), nitrite, nitrate, glucose, fibrinogen triacylglycerol (TG), apolipoprotein A (ApoA1), apolipoprotein B (ApoB100) were all measured before the experiment and three hours after feeding with these treatment diets. Results: In high cholesterol diet fibrinogen, nitrite, glucose, OxLDL, MDA and CRP showed a significant increase compared to normal diet. Significant differences were observed between both groups of apple cider vinegar by fibrinogen in comparison with hypercholesterolemic diet. Using 10ml apple cider vinegar with cholesterolemic diet caused a significant reduction in Ox-LDL, MDA and glucose in comparison with hypercholesterolemic diet. Moreover, the consumption of 5ml apple cider vinegar with cholesterolemic diet caused a significant decrease in LDL-C and TC compared to hypercholesterolemic diet. No significant difference was found between apple cider vinegar taking groups and hypercholesterol diet in CRP, TG ApoA, HDL-C, ApoB, SGOT, SGPT, nitrite and nitrate. Conclusion: The results showed that acute consumption of apple cider vinegar (as an antioxidant) causes significant reduction on some risk factors of atherosclerosis