Qom University of Medical Sciences Journal

Background and Objectives: Epilepsy is one of the central nervous system disorders, which can increase reactive oxygen species and superoxide production. In this research, the effect of hydroalcoholic extract of ginger were evaluated on the reproductive system of epileptic female rats treated with lamotrigine.

Methods: In this research, 36 female Wistar rats were divided into 6 groups of 6 mice each. The first control group was treated with normal saline and the second control group with lamotrigine (10mg/kg) for 4 consecutive weeks. The experiment was continued with epilepsy induction through intraperitoneal injection of pentylenetetrazol (PTZ) (40mg/kg). The first epileptic group received normal saline. The other epileptic group was treated with lamotrigine (10mg/kg). The third epileptic group received ginger at a dose of. The fourth epileptic group simultaneously received ginger and lamotrigine at the same doze. At the end of 28 days, the rats were sacrificed and their blood samples were collected for biochemical analysis, and their reproductive organs were removed. Then, after H&E staining, the numbers of growing, atretic, and cystic follicles were counted by light microscopy.

Results: In epileptic rats, the level of progestron hormone, number of growing follicles and endometrial thickness and glands significantly decreased. Furthermore, the level of estrogene hormone and the number of atretic and cystic follicles significantly increased (p<0.05). While, these parameters were improved in rats treated with hydroalcoholic extract of ginger.

Conclusion: According to the results of this research, hydroalcoholic extract of ginger can have positive effect on the reproductive system in epileptic female rats treated with lamotrigine.