Qom University of Medical Sciences Journal

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Background and Objectives: Type 2 diabetes is one of the most common metabolic diseases and a complex disorder with a strong genetic predisposition, which significantly affects mortality. A series of factors, such as environmental factors and genetic background are involved in the disease. Recently, a new gene associated with type 2 diabetes has been discovered, which is called GFPT2 and is located on the long arm of chromosome 5. Various mutations can alter GFPT2 function and provide risk for diabetes. In this study, the association of GFPT2 gene polymorphism and the risk of type 2 diabetes, was investigated.
 
Methods: In this case-control study, 150 type 2 diabetic patients and 150 healthy individuals, were randomly selected from the research population. GFPT2 gene polymorphism was investigated using PCR-RFLP method. Chi-square test was used to determine the balance or imbalance in the two studied groups, the association between polymorphism and incidence of type 2 diabetes.
 
Results: In this study, a significant difference was observed in the genotype distribution of GFPT2 gene in patients with type 2 diabetes in comparison with the healthy subjects [p= 0.041, (odds ratio: 2.81 (95%CI: 1.02-5.09)].
 
Conclusion: The results of the present study indicated that there is evidence that there is an association between genetic variant of GFPT2 gene and the incidence of type 2 diabetes. Therefore, further studies are necessary to evaluate the importance of genetic variant in different populations.
 
 

Keywords: Human GFPT2 protein, Polymorphism, Genetic, DNA restriction enzymes, Diabetes mellitus.

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