Volume 3, Issue 1 (4-2009)                   Qom Univ Med Sci J 2009, 3(1): 5-12 | Back to browse issues page

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Shahi M, Mahboob S, Haidari F, Rashidi B, Rashidi M. Effect of Isolated Soy Protein on Prevention of Rheumatoid Arthritis in Collagen- Induced Rats. Qom Univ Med Sci J 2009; 3 (1) :5-12
URL: http://journal.muq.ac.ir/article-1-34-en.html
1- Tabriz University of Medical Sciences
2- JundiShapur University of Medical Sciences
3- Tabriz University of Medical Sciences , rashidi@tbzmed.ac.ir
Abstract:   (5863 Views)

Background and Objectives The aim of this study was to investigate the effect of isolated soy protein on prevention of rheumatoid arthritis in collagen-induced rats.   Methods   A total of 24 female Sprague-Dawley rats (body weights: 180-200g) were randomly divided into four equal groups including normal; control of rheumatoid arthritis; rheumatoid arthritis + isolated soy protein (7g/kg); rheumatoid arthritis + dexamethasone (1mg/kg). Experimentally rheumatoid arthritis in rats was induced by subcutaneous injection of collagen ΙΙ emolsified in Incomplete Frund ’ s Adjuvant in days 1 and 7. Treatments were gavaged to animals for 30 days, once a day. The severity of rheumatoid arthritis symptoms in paws were daily measured in double blind format by standard method. The statistical comparison between the experimental groups was performed by Independent -samples t- test and One-Way ANOVA using SPSS software.   Results The clinical symptoms of rheumatoid arthritis started from day 17.4±2.4, 20±4 and 14.1±1.9 in isolated soy protein, dexamethasone and control groups, respectively (P<0.05). The severity of clinical symptoms of rheumatoid arthritis on day 30 was 3.84±2.04, 2±1.78 and 6.5±1.76 in isolated soy protein, dexamethasone and control groups, respectively (P<0.05). At the end of the study, the incidence rates of rheumatoid arthritis in isolated soy protein and control groups was %83.33 and %100, respectively.   Conclusion Isolated soy protein decreased the severity of clinical symptoms of rheumatoid arthritis. Therefore, it could be a key factor in prevention and even treatment of rheumatoid arthritis.

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Type of Study: Original Article |
Received: 2016/02/13 | Accepted: 2016/02/22 | Published: 2016/02/22

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