Qom University of Medical Sciences Journal

Background and Objectives: Peganum Harmala L. (Zygophylaceae) has been used in a variety of practical applications in medical science. The aim of this study was to determine antifungal activity of seed extract of Peganum Harmala against fungal strains.

Methods: In vitro antifungal activities of Alkaloid extract of Peganum Harmalawere tested against Aspergillusniger, Microsporumgypseum, Candida albicans and Saccharomyces cerevisiae. Minimal inhibitory concentration (MIC) was determined using broth microdilution method. After that, the effects of extract were compared with those of miconazole.

Results: Peganum Harmala alkaloid extract had antifungal activity against all the fungi species tested with MIC values ranging from 1 to 3.2 mg/ml.

Conclusion: The results indicate that alkaloid extract of P. Harmala has antifungal activity and might be promising, at least, in treatment of fungal-associated diseases from mentioned fungi.