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nasirizadeh S, Ghasempour A, Rahimi F, Sedighi M. Investigating the Limitation of Porous Nanosystems in Drug Delivery and Its Improvement Strategy. Qom Univ Med Sci J 2025; 19
URL: http://journal.muq.ac.ir/article-1-3831-en.html
URL: http://journal.muq.ac.ir/article-1-3831-en.html
1- Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
2- Student research committee,Mashhad University of Medical Sciences, Mashhad, Iran
3- Division of Nanobiotechnology, Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
4- Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran ,m.sedighi@bums.ac.ir
2- Student research committee,Mashhad University of Medical Sciences, Mashhad, Iran
3- Division of Nanobiotechnology, Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
4- Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran ,
Abstract: (606 Views)
Modern drug delivery strategies using nano-systems have attracted tremendous attention in recent years and among them, there are a large number of studies on silicon-based porous nanosystems due to their impressive features including large surface area, high pore volume, biocompatibility, and biodegradability. Today, most of the studies have focused on the design of smart drug carriers that can specifically respond to physical and chemical changes in the environment such as magnetic field, pH, reducing agents, biomolecules, etc. In addition to the favorable advantages of porous silicon nanosystems, burst release and drug leakage from the pores before reaching the target area have limited the use of these nanoparticles. Therefore, Gatekeepers are suggested as a suitable strategy to solve this challenge and create smart nanosystems, which can be inorganic nanoparticles, polymer coatings, or even a combination of them. Gatekeepers can cover the surface of porous silicon nanosystems to close the pores and prevent drug release before reaching the target area. However, according to the inherent characteristics of the gatekeepers, they can respond to internal or external stimuli in the target area and induce drug release by separating from the surface, by which the occurrence of side effects and uncertainty in determining the effective dose will be prevented. In this study, the limitations of silicon-based nanosystems have been reviewed in the drug delivery field, and the strategies for controlled drug release have been investigated, with a special focus on stimuli-responsive gatekeepers.
Type of Study: Review Article |
Subject:
pharmacology
Received: 2023/10/11 | Accepted: 2023/12/31 | Published: 2025/03/30
Received: 2023/10/11 | Accepted: 2023/12/31 | Published: 2025/03/30
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